Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

Many acute myeloid leukaemias (AMLs) express high levels of BCL-2 and MCL-1, especially after therapy. To test the impact of these anti-apoptotic proteins on AML development and treatment, we used haemopoietic reconstitution to generate MLL-AF9 AMLs expressing BCL-2 or Mcl-1 transgenes. AMLs with el...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Anstee, Natasha S., Bilardi, Rebecca A., Ng, Ashley P., Xu, Zhen, Robati, Mikara, Vandenberg, Cassandra J., Cory, Suzanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748137/
https://ncbi.nlm.nih.gov/pubmed/30470795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0209-1
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