Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice

Inhibition of the apoptosis pathway controlled by opposing members of the Bcl-2 protein family plays a central role in cancer development and resistance to therapy. To investigate how pro-apoptotic Bcl-2 homology domain 3 (BH3)-only proteins impact on acute myeloid leukemia (AML), we generated mixed...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Bilardi, Rebecca A, Anstee, Natasha S, Glaser, Stefan P, Robati, Mikara, Vandenberg, Cassandra J, Cory, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059861/
https://ncbi.nlm.nih.gov/pubmed/27584789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.258
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