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Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau
Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD...
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| Publicat a: | Int J Mol Sci |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6747090/ https://ncbi.nlm.nih.gov/pubmed/31480543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174283 |
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