Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Jeong, Hyeanjeong, Shin, Seulgi, Lee, Jun-Seok, Lee, Soo Hyun, Baik, Ja-Hyun, Lim, Sungsu, Kim, Yun Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747090/
https://ncbi.nlm.nih.gov/pubmed/31480543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174283
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