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Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Jeong, Hyeanjeong, Shin, Seulgi, Lee, Jun-Seok, Lee, Soo Hyun, Baik, Ja-Hyun, Lim, Sungsu, Kim, Yun Kyung
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747090/
https://ncbi.nlm.nih.gov/pubmed/31480543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174283
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