Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Jeong, Hyeanjeong, Shin, Seulgi, Lee, Jun-Seok, Lee, Soo Hyun, Baik, Ja-Hyun, Lim, Sungsu, Kim, Yun Kyung
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747090/
https://ncbi.nlm.nih.gov/pubmed/31480543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174283
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