Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells

Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induce...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Liu, Lu, Zhao, Meiling, Jin, Xi, Ney, Gina, Yang, Kevin B, Peng, Fanglue, Cao, Jin, Iwawaki, Takao, Del Valle, Juan, Chen, Xi, Li, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745703/
https://ncbi.nlm.nih.gov/pubmed/30778220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0285-6
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