Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway

Altered regulation of ER stress response has been implicated in a variety of human diseases, such as cancer and metabolic diseases. Excessive ER function contributes to malignant phenotypes, such as chemoresistance and metastasis. Here we report that the tumor suppressor p53 regulates ER function in...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Namba, Takushi, Chu, Kiki, Kodama, Rika, Byun, Sanguine, Yoon, Kyoung Wan, Hiraki, Masatsugu, Mandinova, Anna, Lee, Sam W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652982/
https://ncbi.nlm.nih.gov/pubmed/26254280
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