Small molecule reactivation of mutant p53 to wt-like p53 through the p53-Hsp40 regulatory axis

TP53 is the most frequently mutated gene in human cancer, and small molecule reactivation of mutant p53 function represents an important anti-cancer strategy. A cell-based high-throughput small molecule screen identified chetomin (CTM) as a mutant p53 R175H reactivator. CTM enabled p53 to transactiv...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Chem Biol
Autori principali: Hiraki, Masatsugu, Hwang, So-Young, Cao, Shugeng, Ramadhar, Timothy R., Byun, Sanguine, Yoon, Kyoung Wan, Lee, Jung Hyun, Chu, Kiki, Gurkar, Aditi U., Kolev, Vihren, Zhang, Jianming, Namba, Takushi, Murphy, Maureen E., Newman, David J., Mandinova, Anna, Clardy, Jon, Lee, Sam W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670040/
https://ncbi.nlm.nih.gov/pubmed/26320861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.07.016
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi