Small molecule reactivation of mutant p53 to wt-like p53 through the p53-Hsp40 regulatory axis

TP53 is the most frequently mutated gene in human cancer, and small molecule reactivation of mutant p53 function represents an important anti-cancer strategy. A cell-based high-throughput small molecule screen identified chetomin (CTM) as a mutant p53 R175H reactivator. CTM enabled p53 to transactiv...

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Veröffentlicht in:Chem Biol
Hauptverfasser: Hiraki, Masatsugu, Hwang, So-Young, Cao, Shugeng, Ramadhar, Timothy R., Byun, Sanguine, Yoon, Kyoung Wan, Lee, Jung Hyun, Chu, Kiki, Gurkar, Aditi U., Kolev, Vihren, Zhang, Jianming, Namba, Takushi, Murphy, Maureen E., Newman, David J., Mandinova, Anna, Clardy, Jon, Lee, Sam W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670040/
https://ncbi.nlm.nih.gov/pubmed/26320861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.07.016
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