PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1–Xbp1s pathway expedites liver injury

OBJECTIVE: Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the regulatory basis. DESIGN: Hepati...

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Detalles Bibliográficos
Publicado en:Gut
Main Authors: Han, Chang Yeob, Lim, Sang Woo, Koo, Ja Hyun, Kim, Won, Kim, Sang Geon
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2016
Assuntos:
Hepatology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975835/
https://ncbi.nlm.nih.gov/pubmed/25966993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308506
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