Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

The mineralocorticoid receptor (MR) is highly conserved across vertebrate evolution. In terrestrial vertebrates, the MR mediates sodium homeostasis by aldosterone and also acts as a receptor for cortisol. Although the MR is present in fish, they lack aldosterone. The MR binds progesterone and spiron...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fuller, Peter J., Yao, Yi-Zhou, Jin, Ruitao, He, Sitong, Martín-Fernández, Beatriz, Young, Morag J., Smith, Brian J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744879/
https://ncbi.nlm.nih.gov/pubmed/31439819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903172116
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker