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Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist
The mineralocorticoid receptor (MR) is highly conserved across vertebrate evolution. In terrestrial vertebrates, the MR mediates sodium homeostasis by aldosterone and also acts as a receptor for cortisol. Although the MR is present in fish, they lack aldosterone. The MR binds progesterone and spiron...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744879/ https://ncbi.nlm.nih.gov/pubmed/31439819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903172116 |
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