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Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display
The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily. Pathological activation of the MR causes cardiac fibrosis and heart failure, but clinical use of MR antagonists is limited by the renal side effect of hyperkalemia. The glucocorticoid cortisol binds the MR with equi...
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| Publicado no: | Mol Endocrinol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417296/ https://ncbi.nlm.nih.gov/pubmed/21106883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0193 |
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