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Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display
The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily. Pathological activation of the MR causes cardiac fibrosis and heart failure, but clinical use of MR antagonists is limited by the renal side effect of hyperkalemia. The glucocorticoid cortisol binds the MR with equi...
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| Udgivet i: | Mol Endocrinol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Endocrine Society
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5417296/ https://ncbi.nlm.nih.gov/pubmed/21106883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0193 |
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