Identification of Ligand-Selective Peptide Antagonists of the Mineralocorticoid Receptor Using Phage Display

The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily. Pathological activation of the MR causes cardiac fibrosis and heart failure, but clinical use of MR antagonists is limited by the renal side effect of hyperkalemia. The glucocorticoid cortisol binds the MR with equi...

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Bibliografiske detaljer
Udgivet i:Mol Endocrinol
Main Authors: Yang, Jun, Chang, Ching-yi, Safi, Rachid, Morgan, James, McDonnell, Donald P., Fuller, Peter J., Clyne, Colin D., Young, Morag J.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2011
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417296/
https://ncbi.nlm.nih.gov/pubmed/21106883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0193
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