USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

Axin is a key scaffolding protein responsible for the formation of the β-catenin destruction complex. Stability of Axin protein is regulated by the ubiquitin-proteasome system, and modulation of cellular concentration of Axin protein has a profound effect on Wnt/β-catenin signaling. Although E3s pro...

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Udgivet i:Nat Commun
Main Authors: Ji, Lei, Lu, Bo, Zamponi, Raffaella, Charlat, Olga, Aversa, Robert, Yang, Zinger, Sigoillot, Frederic, Zhu, Xiaoping, Hu, Tiancen, Reece-Hoyes, John S., Russ, Carsten, Michaud, Gregory, Tchorz, Jan S., Jiang, Xiaomo, Cong, Feng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744515/
https://ncbi.nlm.nih.gov/pubmed/31519875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12143-3
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