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Wnt-induced dephosphorylation of Axin releases β-catenin from the Axin complex
The stabilization of β-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3β are implicated in regulating β-catenin phosphorylation and its subsequent degradation. Wnt signaling s...
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| Udgivet i: | Genes Dev |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
1999
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10421629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.14.1768 |
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