Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

The Wnt pathway controls numerous developmental processes via the β-catenin–TCF/LEF transcription complex. Deregulation of the pathway results in the aberrant accumulation of β-catenin in the nucleus, often leading to cancer. Normally, cytoplasmic β-catenin associates with APC and axin and is contin...

Full beskrivning

Bibliografiska uppgifter

I publikationen:	Genes Dev
Huvudupphov:	Amit, Sharon, Hatzubai, Ada, Birman, Yaara, Andersen, Jens S., Ben-Shushan, Etti, Mann, Matthias, Ben-Neriah, Yinon, Alkalay, Irit
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Cold Spring Harbor Laboratory Press 2002
Ämnen:	Research Paper
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12000790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.230302
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!