Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

The Wnt pathway controls numerous developmental processes via the β-catenin–TCF/LEF transcription complex. Deregulation of the pathway results in the aberrant accumulation of β-catenin in the nucleus, often leading to cancer. Normally, cytoplasmic β-catenin associates with APC and axin and is contin...

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Главные авторы: Amit, Sharon, Hatzubai, Ada, Birman, Yaara, Andersen, Jens S., Ben-Shushan, Etti, Mann, Matthias, Ben-Neriah, Yinon, Alkalay, Irit
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2002
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC186245/
https://ncbi.nlm.nih.gov/pubmed/12000790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.230302
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