Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

The Wnt pathway controls numerous developmental processes via the β-catenin–TCF/LEF transcription complex. Deregulation of the pathway results in the aberrant accumulation of β-catenin in the nucleus, often leading to cancer. Normally, cytoplasmic β-catenin associates with APC and axin and is contin...

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Bibliografiske detaljer

Udgivet i:	Genes Dev
Principais autores:	Amit, Sharon, Hatzubai, Ada, Birman, Yaara, Andersen, Jens S., Ben-Shushan, Etti, Mann, Matthias, Ben-Neriah, Yinon, Alkalay, Irit
Format:	Artigo
Sprog:	Inglês
Udgivet:	Cold Spring Harbor Laboratory Press 2002
Fag:	Research Paper
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12000790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.230302
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