mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

Wnt/β-catenin signaling plays pivotal roles in cell proliferation and tissue homeostasis by maintaining somatic stem cell functions. The mammalian target of rapamycin (mTOR) signaling functions as an integrative rheostat that orchestrates various cellular and metabolic activities that shape tissue h...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zeng, Hao, Lu, Bo, Zamponi, Raffaella, Yang, Zinger, Wetzel, Kristie, Loureiro, Joseph, Mohammadi, Sina, Beibel, Martin, Bergling, Sebastian, Reece-Hoyes, John, Russ, Carsten, Roma, Guglielmo, Tchorz, Jan S., Capodieci, Paola, Cong, Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217415/
https://ncbi.nlm.nih.gov/pubmed/30297426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808575115
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