mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

Wnt/β-catenin signaling plays pivotal roles in cell proliferation and tissue homeostasis by maintaining somatic stem cell functions. The mammalian target of rapamycin (mTOR) signaling functions as an integrative rheostat that orchestrates various cellular and metabolic activities that shape tissue h...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Zeng, Hao, Lu, Bo, Zamponi, Raffaella, Yang, Zinger, Wetzel, Kristie, Loureiro, Joseph, Mohammadi, Sina, Beibel, Martin, Bergling, Sebastian, Reece-Hoyes, John, Russ, Carsten, Roma, Guglielmo, Tchorz, Jan S., Capodieci, Paola, Cong, Feng
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217415/
https://ncbi.nlm.nih.gov/pubmed/30297426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808575115
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