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Tissue specificity of DNA damage response and tumorigenesis

The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents. These damages could potentially lead to genomic instability and thus to tumorigenesis. To cope with the threats, cells have evolved an intricate network, namely DNA damage response (DDR)...

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Detalhes bibliográficos
Publicado no:Cancer Biol Med
Main Authors: Sun, Siman, Osterman, Michael D., Li, Mo
Formato: Artigo
Idioma:Inglês
Publicado em: Chinese Anti-Cancer Association 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743622/
https://ncbi.nlm.nih.gov/pubmed/31565474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2019.0097
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