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DNA Damage Response and Tumorigenesis in Mcm2 Deficient Mice
Mini-chromosome maintenance proteins (Mcm’s) are components of the DNA replication licensing complex. In vivo, reduced expression or activity of Mcm proteins has been shown to result in highly penetrant early onset cancers (Shima et al., 2007; Pruitt et al., 2007 and stem cell deficiencies (Pruitt e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892019/ https://ncbi.nlm.nih.gov/pubmed/20440269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.125 |
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