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DNA Damage Response and Tumorigenesis in Mcm2 Deficient Mice

Mini-chromosome maintenance proteins (Mcm’s) are components of the DNA replication licensing complex. In vivo, reduced expression or activity of Mcm proteins has been shown to result in highly penetrant early onset cancers (Shima et al., 2007; Pruitt et al., 2007 and stem cell deficiencies (Pruitt e...

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Bibliografiske detaljer
Main Authors: Kunnev, Dimiter, Rusiniak, Michael E., Kudla, Angela, Freeland, Amy, Cady, Gillian K., Pruitt, Steven C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892019/
https://ncbi.nlm.nih.gov/pubmed/20440269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.125
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