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A Signature of Genomic Instability Resulting from Deficient Replication Licensing

Insufficient licensing of DNA replication origins has been shown to result in genome instability, stem cell deficiency, and cancers. However, it is unclear whether the DNA damage resulting from deficient replication licensing occurs generally or if specific sites are preferentially affected. To map...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pruitt, Steven C., Qin, Maochun, Wang, Jianmin, Kunnev, Dimiter, Freeland, Amy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242545/
https://ncbi.nlm.nih.gov/pubmed/28045896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006547
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