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Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

Nonheme diiron monooxygenases make up a rapidly growing family of oxygenases that are rarely identified in secondary metabolism. Herein, we report the in vivo, in vitro, and structural characterizations of a nonheme diiron monooxygenase, PtmU3, that installs a C-5 β-hydroxyl group in the unified bio...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Dong, Liao-Bin, Liu, Yu-Chen, Cepeda, Alexis J., Kalkreuter, Edward, Deng, Ming-Rong, Rudolf, Jeffrey D., Chang, Changsoo, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743330/
https://ncbi.nlm.nih.gov/pubmed/31291107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06183
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