The Binding of 2-(4′-Methylaminophenyl)Benzothiazole to Postmortem Brain Homogenates Is Dominated by the Amyloid Component

2-(4′-Methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Aβ fibrils and shows very good brain entry and clearance. In this study, we asked whether BTA-1, at concentrations typical of those achieved during positron emission tomography (PET) s...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Klunk, William E., Wang, Yanming, Huang, Guo-feng, Debnath, Manik L., Holt, Daniel P., Shao, Li, Hamilton, Ronald L., Ikonomovic, Milos D., DeKosky, Steven T., Mathis, Chester A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741999/
https://ncbi.nlm.nih.gov/pubmed/12657667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-06-02086.2003
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