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Synthesis and β-amyloid binding properties of rhenium 2-phenylbenzothiazoles
As a first step toward the development of (99m)Tc PiB analogs, we have synthesized six neutral Re 2-phenylbenzothiazoles via pendant or integrated approach. These Re compounds bind to Aβ(1–40) fibrils with fairly good affinities (K(i) = 10.0–88.6 nM) and have moderate lipophilicities (logP(C18) = 1....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683665/ https://ncbi.nlm.nih.gov/pubmed/19285394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.096 |
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