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Synthesis and β-amyloid binding properties of rhenium 2-phenylbenzothiazoles

As a first step toward the development of (99m)Tc PiB analogs, we have synthesized six neutral Re 2-phenylbenzothiazoles via pendant or integrated approach. These Re compounds bind to Aβ(1–40) fibrils with fairly good affinities (K(i) = 10.0–88.6 nM) and have moderate lipophilicities (logP(C18) = 1....

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Bibliografiske detaljer
Main Authors: Lin, Kuo-Shyan, Debnath, Manik L., Mathis, Chester A., Klunk, William E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683665/
https://ncbi.nlm.nih.gov/pubmed/19285394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.096
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