Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain

During the development of in vivo amyloid imaging agents, an effort was made to use micro-positron emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor protein (APP) transgenic mouse model of CNS amyloid deposition to screen new compounds and further study Pittsburgh Compoun...

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Vydáno v:J Neurosci
Hlavní autoři: Klunk, William E., Lopresti, Brian J., Ikonomovic, Milos D., Lefterov, Iliya M., Koldamova, Radosveta P., Abrahamson, Eric E., Debnath, Manik L., Holt, Daniel P., Huang, Guo-feng, Shao, Li, DeKosky, Steven T., Price, Julie C., Mathis, Chester A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725842/
https://ncbi.nlm.nih.gov/pubmed/16291932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2990-05.2005
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