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Neuroprotective Activity of 3‐Aminopyridine‐2‐Carboxaldehyde Thiosemicarbazone (PAN‐811), a Cancer Therapeutic Agent
3‐aminopyridine‐2‐carboxaldehyde thiosemicarbazone (3‐AP) is a highly‐hydrophobic small molecule that was originally developed for cancer therapy (Triapine®, Vion Pharmaceuticals) due to its ability to inhibit ribonucleotide reductase, a key enzyme required for DNA synthesis. 3‐AP has a high affinit...
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| Publicado en: | CNS Drug Rev |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Publishing Inc
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6741723/ https://ncbi.nlm.nih.gov/pubmed/16834759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1527-3458.2006.00077.x |
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