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Neuroprotective Activity of 3‐Aminopyridine‐2‐Carboxaldehyde Thiosemicarbazone (PAN‐811), a Cancer Therapeutic Agent

3‐aminopyridine‐2‐carboxaldehyde thiosemicarbazone (3‐AP) is a highly‐hydrophobic small molecule that was originally developed for cancer therapy (Triapine®, Vion Pharmaceuticals) due to its ability to inhibit ribonucleotide reductase, a key enzyme required for DNA synthesis. 3‐AP has a high affinit...

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Vydáno v:CNS Drug Rev
Hlavní autoři: Jiang, Zhi‐Gang, Lebowitz, Michael S., Ghanbari, Hossein A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Inc 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741723/
https://ncbi.nlm.nih.gov/pubmed/16834759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1527-3458.2006.00077.x
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