Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in Advanced-Stage Cervical and Vaginal Cancers

OBJECTIVE: Cervical and vaginal cancers have virally-mediated or mutated defects in DNA damage repair responses, making these cancers sensible targets for ribonucleotide reductase inhibition during radiochemotherapy. METHODS: We conducted a phase II study evaluating 3x weekly 2-hour intravenous 3-am...

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Publicado no:Gynecol Oncol
Main Authors: Kunos, Charles A., Radivoyevitch, Tomas, Waggoner, Steven, Debernardo, Robert, Zanotti, Kristine, Resnick, Kimberly, Fusco, Nancy, Adams, Ramon, Redline, Raymond, Faulhaber, Peter, Dowlati, Afshin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260802/
https://ncbi.nlm.nih.gov/pubmed/23603372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2013.04.019
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