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Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in Advanced-Stage Cervical and Vaginal Cancers
OBJECTIVE: Cervical and vaginal cancers have virally-mediated or mutated defects in DNA damage repair responses, making these cancers sensible targets for ribonucleotide reductase inhibition during radiochemotherapy. METHODS: We conducted a phase II study evaluating 3x weekly 2-hour intravenous 3-am...
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Udgivet i: | Gynecol Oncol |
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Main Authors: | , , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
2013
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4260802/ https://ncbi.nlm.nih.gov/pubmed/23603372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2013.04.019 |
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