Population Pharmacokinetics of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (Triapine®) in Cancer Patients

PURPOSE: The purpose of this study was to develop a population pharmacokinetic (PK) model for 3-AP pharmacokinetics and to evaluate the effect of ABCB1 polymorphisms on the pharmacokinetic profile of 3-AP and to assess the relationship between 3AP disposition and patient covariates. METHODS: A total...

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Detalhes bibliográficos
Main Authors: Kolesar, Jill, Brundage, Richard C., Pomplun, Marcia, Alberti, Dona, Holen, Kyle, Traynor, Anne, Ivy, Percy, Wilding, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059107/
https://ncbi.nlm.nih.gov/pubmed/20440618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1331-z
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