The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors

PURPOSE: 3-AP is a ribonucleotide reductase inhibitor and has been postulated to act synergistically with other chemotherapeutic agents. This study was conducted to determine the toxicity and antitumor activity of 3-AP with irinotecan. Correlative studies included pharmacokinetics and the effects of...

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Main Authors: Choi, Brian S., Alberti, Dona B., Schelman, William R., Kolesar, Jill M., Thomas, James P., Marnocha, Rebecca, Eickhoff, Jens C., Ivy, S. Percy, Wilding, George, Holen, Kyle D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921466/
https://ncbi.nlm.nih.gov/pubmed/20127092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1250-z
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