Cytotoxic evaluation of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in peripheral blood lymphocytes of patients with refractory solid tumors using electron paramagnetic resonance

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a metal chelator that potently inhibits the enzyme ribonucleotide reductase (RR), which plays a key role in cell division and tumor progression. A subunit of RR has a non-heme iron and a tyrosine-free radical, which are required for the en...

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Main Authors: KOLESAR, JILL M., SACHIDANANDAM, KAMAKSHI, SCHELMAN, WILLIAM R., EICKHOFF, JENS, HOLEN, KYLE D., TRAYNOR, ANNE M., ALBERTI, DONA B., THOMAS, JAMES P., CHITAMBAR, CHRISTOPHER R., WILDING, GEORGE, ANTHOLINE, WILLIAM E.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046871/
https://ncbi.nlm.nih.gov/pubmed/21373381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2010.165
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