Electron Paramagnetic Resonance Study of Peripheral Blood Mononuclear Cells from Patients with Refractory Solid Tumors Treated with Triapine(®)

The metal chelator Triapine(®), 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, is a potent inhibitor of ribonucleotide reductase. EPR spectra consistent with signals from Fe-transferrin, heme, and low-spin iron or cupric ion were observed in peripheral blood mononuclear cells (PBMCs) obtained f...

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Autori principali: Kolesar, Jill M., Schelman, William R., Geiger, Peter G., Holen, Kyle D., Traynor, Anne M., Alberti, Dona B., Thomas, James P., Chitambar, Christopher R., Wilding, George, Antholine, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390869/
https://ncbi.nlm.nih.gov/pubmed/18061679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2007.10.013
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