Cytotoxic evaluation of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in peripheral blood lymphocytes of patients with refractory solid tumors using electron paramagnetic resonance

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a metal chelator that potently inhibits the enzyme ribonucleotide reductase (RR), which plays a key role in cell division and tumor progression. A subunit of RR has a non-heme iron and a tyrosine-free radical, which are required for the en...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: KOLESAR, JILL M., SACHIDANANDAM, KAMAKSHI, SCHELMAN, WILLIAM R., EICKHOFF, JENS, HOLEN, KYLE D., TRAYNOR, ANNE M., ALBERTI, DONA B., THOMAS, JAMES P., CHITAMBAR, CHRISTOPHER R., WILDING, GEORGE, ANTHOLINE, WILLIAM E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: D.A. Spandidos 2011
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046871/
https://ncbi.nlm.nih.gov/pubmed/21373381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2010.165
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia