Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP) is currently the most promising chemotherapeutic compound among the class of α-N-heterocyclic thiosemicarbazones. Here we report further insights into the mechanism(s) of anticancer drug activity and inhibition of mouse ribonucleoti...

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Main Authors: Popović-Bijelić, Ana, Kowol, Christian R., Lind, Maria E.S., Luo, Jinghui, Himo, Fahmi, Enyedy, Éva A., Arion, Vladimir B., Gräslund, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374975/
https://ncbi.nlm.nih.gov/pubmed/21955844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2011.07.003
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