Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae

Streptococcus pneumoniae is a common cause of pneumonia and sepsis. Toll-like receptors (TLRs) play a pivotal role in the host defense against infection. In this study, we sought to determine the role of single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR a.k.a. TIR8), a negative r...

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Udgivet i:J Innate Immun
Main Authors: Blok, Dana C., van Lieshout, Miriam H.P., Hoogendijk, Arie J., Florquin, Sandrine, de Boer, Onno J., Garlanda, Cecilia, Mantovani, Alberto, van't Veer, Cornelis, de Vos, Alex F., van der Poll, Tom
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741518/
https://ncbi.nlm.nih.gov/pubmed/24556793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358239
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