Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae

Streptococcus pneumoniae is a common cause of pneumonia and sepsis. Toll-like receptors (TLRs) play a pivotal role in the host defense against infection. In this study, we sought to determine the role of single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR a.k.a. TIR8), a negative r...

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Publicado en:J Innate Immun
Main Authors: Blok, Dana C., van Lieshout, Miriam H.P., Hoogendijk, Arie J., Florquin, Sandrine, de Boer, Onno J., Garlanda, Cecilia, Mantovani, Alberto, van't Veer, Cornelis, de Vos, Alex F., van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado: S. Karger AG 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741518/
https://ncbi.nlm.nih.gov/pubmed/24556793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358239
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