TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-γ

Klebsiella pneumoniae is an important cause of Gram-negative pneumonia and sepsis. Mice deficient for TIR-domain-containing adaptor-inducing interferon-β (TRIF) demonstrate enhanced bacterial growth and dissemination during Klebsiella pneumonia. We show here that the impaired antibacterial defense o...

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Vydáno v:J Innate Immun
Hlavní autoři: van Lieshout, Miriam H.P., Florquin, Sandrine, vanʼt Veer, Cornelis, de Vos, Alex F., van der Poll, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: S. Karger AG 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738753/
https://ncbi.nlm.nih.gov/pubmed/26065469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000430913
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