Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae

Streptococcus pneumoniae is a common cause of pneumonia and sepsis. Toll-like receptors (TLRs) play a pivotal role in the host defense against infection. In this study, we sought to determine the role of single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR a.k.a. TIR8), a negative r...

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Bibliographic Details
Published in:J Innate Immun
Main Authors: Blok, Dana C., van Lieshout, Miriam H.P., Hoogendijk, Arie J., Florquin, Sandrine, de Boer, Onno J., Garlanda, Cecilia, Mantovani, Alberto, van't Veer, Cornelis, de Vos, Alex F., van der Poll, Tom
Format: Artigo
Language:Inglês
Published: S. Karger AG 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741518/
https://ncbi.nlm.nih.gov/pubmed/24556793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358239
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