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Reduction of Detyrosinated Microtubules and Golgi Fragmentation Are Linked to Tau-Induced Degeneration in Astrocytes

Several human neurodegenerative diseases are associated with abnormal accumulations of aggregated tau proteins and glial degeneration in astrocytes, but the mechanism whereby tau proteins cause astrocytic degeneration is unclear. Here, we analyzed the biological consequences of overexpressing the lo...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Yoshiyama, Yasumasa, Zhang, Bin, Bruce, Jennifer, Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740917/
https://ncbi.nlm.nih.gov/pubmed/14627651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-33-10662.2003
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