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Reduction of Detyrosinated Microtubules and Golgi Fragmentation Are Linked to Tau-Induced Degeneration in Astrocytes

Several human neurodegenerative diseases are associated with abnormal accumulations of aggregated tau proteins and glial degeneration in astrocytes, but the mechanism whereby tau proteins cause astrocytic degeneration is unclear. Here, we analyzed the biological consequences of overexpressing the lo...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Yoshiyama, Yasumasa, Zhang, Bin, Bruce, Jennifer, Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740917/
https://ncbi.nlm.nih.gov/pubmed/14627651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-33-10662.2003
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