Analysis of Neurons Created from Wild-Type and Alzheimer's Mutation Knock-In Embryonic Stem Cells by a Highly Efficient Differentiation Protocol

It is impossible to obtain and amplify live neurons from Alzheimer's disease (AD) patients. To establish the neurons harboring AD abnormality, we constructed mouse embryonic stem (ES) cells, in which the AD-causative V642I mutation was introduced to the endogenous amyloid precursor protein (APP...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Abe, Yoichiro, Kouyama, Keisuke, Tomita, Taisuke, Tomita, Yusuke, Ban, Norimitsu, Nawa, Mikiro, Matsuoka, Masaaki, Niikura, Takako, Aiso, Sadakazu, Kita, Yoshiko, Iwatsubo, Takeshi, Nishimoto, Ikuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2003
Schlagworte:
Development/Plasticity/Repair
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740361/
https://ncbi.nlm.nih.gov/pubmed/13679420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-24-08513.2003
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