Humanin and Colivelin: Neuronal‐Death‐Suppressing Peptides for Alzheimer's Disease and Amyotrophic Lateral Sclerosis

Humanin (HN), a 24‐amino‐acid neuroprotective peptide, was originally found in the occipital lobe of an autopsied Alzheimer's disease (AD) patient. HN inhibits neuronal death by binding to its specific receptor on the cell membrane and triggering a Jak2/STAT3 prosurvival pathway. The activation...

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Bibliografiske detaljer
Udgivet i:CNS Drug Rev
Main Authors: Matsuoka, Masaaki, Hashimoto, Yuichi, Aiso, Sadakazu, Nishimoto, Ikuo
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Inc 2006
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494132/
https://ncbi.nlm.nih.gov/pubmed/16958985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1527-3458.2006.00113.x
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