D-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

Excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). More recently, glial involvement has been shown to be essential for ALS-related motoneuronal death. Here, we identified an N-methyl-D-aspartate (NMDA) receptor co-agonist, D-serine (D-Ser), as a glia-deriv...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sasabe, Jumpei, Chiba, Tomohiro, Yamada, Marina, Okamoto, Koichi, Nishimoto, Ikuo, Matsuoka, Masaaki, Aiso, Sadakazu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2007
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230675/
https://ncbi.nlm.nih.gov/pubmed/17762863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601840
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