D-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

Excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). More recently, glial involvement has been shown to be essential for ALS-related motoneuronal death. Here, we identified an N-methyl-D-aspartate (NMDA) receptor co-agonist, D-serine (D-Ser), as a glia-deriv...

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Hlavní autoři: Sasabe, Jumpei, Chiba, Tomohiro, Yamada, Marina, Okamoto, Koichi, Nishimoto, Ikuo, Matsuoka, Masaaki, Aiso, Sadakazu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230675/
https://ncbi.nlm.nih.gov/pubmed/17762863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601840
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