Transforming Growth Factor β2 Is a Neuronal Death-Inducing Ligand for Amyloid-β Precursor Protein

APP, amyloid β precursor protein, is linked to the onset of Alzheimer's disease (AD). We have here found that transforming growth factor β2 (TGFβ2), but not TGFβ1, binds to APP. The binding affinity of TGFβ2 to APP is lower than the binding affinity of TGFβ2 to the TGFβ receptor. On binding to...

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Autori principali: Hashimoto, Yuichi, Chiba, Tomohiro, Yamada, Marina, Nawa, Mikiro, Kanekura, Kohsuke, Suzuki, Hiroaki, Terashita, Kenzo, Aiso, Sadakazu, Nishimoto, Ikuo, Matsuoka, Masaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265827/
https://ncbi.nlm.nih.gov/pubmed/16227582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9304-9317.2005
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