Transforming Growth Factor β2 Is a Neuronal Death-Inducing Ligand for Amyloid-β Precursor Protein

APP, amyloid β precursor protein, is linked to the onset of Alzheimer's disease (AD). We have here found that transforming growth factor β2 (TGFβ2), but not TGFβ1, binds to APP. The binding affinity of TGFβ2 to APP is lower than the binding affinity of TGFβ2 to the TGFβ receptor. On binding to...

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Detaylı Bibliyografya
Asıl Yazarlar: Hashimoto, Yuichi, Chiba, Tomohiro, Yamada, Marina, Nawa, Mikiro, Kanekura, Kohsuke, Suzuki, Hiroaki, Terashita, Kenzo, Aiso, Sadakazu, Nishimoto, Ikuo, Matsuoka, Masaaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265827/
https://ncbi.nlm.nih.gov/pubmed/16227582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9304-9317.2005
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