Transforming Growth Factor β2 Is a Neuronal Death-Inducing Ligand for Amyloid-β Precursor Protein

APP, amyloid β precursor protein, is linked to the onset of Alzheimer's disease (AD). We have here found that transforming growth factor β2 (TGFβ2), but not TGFβ1, binds to APP. The binding affinity of TGFβ2 to APP is lower than the binding affinity of TGFβ2 to the TGFβ receptor. On binding to...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hashimoto, Yuichi, Chiba, Tomohiro, Yamada, Marina, Nawa, Mikiro, Kanekura, Kohsuke, Suzuki, Hiroaki, Terashita, Kenzo, Aiso, Sadakazu, Nishimoto, Ikuo, Matsuoka, Masaaki
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2005
विषय:
Gene Expression
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265827/
https://ncbi.nlm.nih.gov/pubmed/16227582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9304-9317.2005
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