An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling

A missense mutation (T835M) in the uncoordinated-5C (UNC5C) netrin receptor gene increases the risk of late-onset Alzheimer disease (AD) and also the vulnerability of neurons harboring the mutation to various insults. The molecular mechanisms underlying T835M-UNC5C-induced death remain to be elucida...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Hashimoto, Yuichi, Toyama, Yuka, Kusakari, Shinya, Nawa, Mikiro, Matsuoka, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933276/
https://ncbi.nlm.nih.gov/pubmed/27068745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698092
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