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Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production
The β-amyloid precursor protein (APP) is an orphan transmembrane receptor whose physiological role is largely unknown. APP is cleaved by proteases generating amyloid-β (Aβ) peptide, the main component of the amyloid plaques that are associated with Alzheimer’s disease. Here, we show that APP binds n...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757418/ https://ncbi.nlm.nih.gov/pubmed/19148186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.191 |
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