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Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions
Amyloid β-protein precursor (APP), a type I membrane protein, is cleaved by primary α-or β-secretase and secondary γ-secretase. Cleavage of APP by β- and γ-secretases generates amyloid β-protein, the main constituent of the cerebrovascular amyloid that accompanies Alzheimer disease. The generation a...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662050/ https://ncbi.nlm.nih.gov/pubmed/18650433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R800003200 |
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