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Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

Amyloid β-protein precursor (APP), a type I membrane protein, is cleaved by primary α-or β-secretase and secondary γ-secretase. Cleavage of APP by β- and γ-secretases generates amyloid β-protein, the main constituent of the cerebrovascular amyloid that accompanies Alzheimer disease. The generation a...

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Bibliografiske detaljer
Main Authors: Suzuki, Toshiharu, Nakaya, Tadashi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662050/
https://ncbi.nlm.nih.gov/pubmed/18650433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R800003200
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