The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

The amyloid precursor protein (APP) is cleaved to produce the Alzheimer disease-associated peptide Aβ, but the normal functions of uncleaved APP in the brain are unknown. We found that APP was present in the postsynaptic density of central excitatory synapses and coimmunoprecipitated with N-methyl-d...

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Detalhes bibliográficos
Main Authors: Hoe, Hyang-Sook, Fu, Zhanyan, Makarova, Alexandra, Lee, Ji-Yun, Lu, Congyi, Feng, Li, Pajoohesh-Ganji, Ahdeah, Matsuoka, Yasuji, Hyman, Bradley T., Ehlers, Michael D., Vicini, Stefano, Pak, Daniel T. S., Rebeck, G. William
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659208/
https://ncbi.nlm.nih.gov/pubmed/19164281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900141200
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